Life Science cross-RI (Research Infrastructure) project

Version 1

The project allowed us to manage and build structured code scripts on the Jupyter Notebook, a simple web application which is user-friendly, flexible to use in the research community. The script is developed to address the specific needs of research between different platforms of dataset. These stakeholders have developed their own platforms for the annotation and standardisation of both data and metadata produced within their respective field. -The INFRAFRONTIER - European Mutant Mouse Archive (EMMA) comprises over 7200 mutant mouse lines that are extensively integrated and enriched with other public dataset. -The EU-OpenScreen offers compound screening protocols containing several metadata and will contribute to the development of tools for linking to the chemical entity database. -The IDR Image Data Resource is a public repository of reference image datasets from published scientific studies, where the community can submit, search and access high-quality bio-image data. -The CIM-XNAT is an XNAT deployment of the Molecular Imaging Center at UniTo that offers a suite of tools for uploading preclinical images. To address the challenges of integrating several EU-RI datasets with focus on preclinical and discovery research bioimaging, our aim is to develop cross researching queries through a web based interface to combine the resources of the RIs for integrating the information associated with data belonging to the involved RIs. Furthermore, the open-source tool provides users with free, open access to collections of datasets distributed over multiple sources that result from searches by specific keywords. The script allows the cross research in different fields of research as: Species, Strain, Gene, Cell line, Disease model, Chemical Compound. The novel aspects of this tool are mainly: a) user friendly, e.g. the user has the flexibility to research among the dataset easily with a simple API, intuitive for researchers and biomedical users.
b) the possibility of making a research between different platforms and repositories, from a unique simple way. c) the workflow project follows the FAIR principles in the treatment of data and datasets. The access to Notebook Jupyter needs the installation of Anaconda, which consents to open the web application. Inside the Jupyter, the script was built using Python. The query code is also easy to download and share in a .ipynb file. A visual representation of the detailed results (dataset, metadata, information, query results) of the workflow can be printed immediately after the query run.