Computational Algorithms for Protein Structures and Interactions - Inria, CNRS, University of Lorraine The CAPSID team develops algorithms and software to help study biological systems and phenomena from a structural point of view. In particular, the team aims to develop algorithms to facilitate and improve the 3D modeling of large multi-component bio-molecular machines.

Protein domains can be viewed as building blocks, essential for understanding structure-function relationships in proteins. However, each domain database classifies protein domains using its own methodology. Thus, in many cases, boundaries between different domains or families differ from one domain database to the other, raising the question of domain definition and enumeration. The answer to this question cannot be found in a single database. Rather, expert integration and curation of various ...

CroMaSt: A workflow for assessing protein domain classification by cross-mapping of structural instances between domain databases and structural alignment

CroMaSt (Cross Mapper of domain Structural instances) is an automated iterative workflow to clarify the assignment of protein domains to a given domain type of interest, based on their 3D structure and by cross-mapping of domain structural instances between domain databases. CroMaSt (for Cross-Mapper of domain Structural instances) ...