Use Case 5: Small Molecules to Induce a Biological Process

Version 1

The workflow starts with selecting Autophagy as the search term. Gene sets with set labels containing Autophagy were queried from Enrichr[1]. Identified matching terms from the MGI Mammalian Phenotype Level 4 2019[2] library were assembled into a collection of gene sets. A GMT was extracted from the Enrichr results for MGI_Mammalian_Phenotype_Level_4_2019. All the identified gene sets were combined using the union set operation. Reversers and mimickers from over 1 million signatures were identified using SigCom LINCS[4]. Resolved drugs from the LINCS L1000 Chemical Perturbagens library. Identified matching terms from the KEGG 2021 Human[6] library were assembled into a collection of gene sets. A GMT was extracted from the Enrichr results for KEGG_2021_Human. All the identified gene sets were combined using the union set operation. Reversers and mimickers from over 1 million signatures were identified using SigCom LINCS[4]. Identified matching terms from the GO Biological Process 2021[7] library were assembled into a collection of gene sets. A GMT was extracted from the Enrichr results for GO_Biological_Process_2021. All the identified gene sets were combined using the union set operation. Reversers and mimickers from over 1 million signatures were identified using SigCom LINCS[4]. Resolved drugs from the LINCS L1000 Chemical Perturbagens library. Resolved drugs from the LINCS L1000 Chemical Perturbagens library. The mean across multiple Scored Drugs is computed. The drugs were filtered by FDA Approved Drugs with the help of PubChem APIs[8].

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