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Workflow Type: Nextflow

Parabricks-Genomics-nf is a GPU-enabled pipeline for alignment and germline short variant calling for short read sequencing data. The pipeline utilises NVIDIA's Clara Parabricks toolkit to dramatically speed up the execution of best practice bioinformatics tools. Currently, this pipeline is configured specifically for NCI's Gadi HPC.

NVIDIA's Clara Parabricks can deliver a significant speed improvement over traditional CPU-based methods, and is designed to be used only with NVIDIA GPUs. This pipeline is suitable for population screening projects as it executes Parabrick's implementations of BWA mem for short read alignment and Google's DeepVariant for short variant calling. Additionally, it uses standard CPU implementations of data quality evaluation tools FastQC and MultiQC and DNAnexus' GLnexus for scalable gVCF merging and joint variant calling. Optionally, Variant Effect Predictor (VEP) can be run for variant annotation.

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main @ 8eea47c (earliest) Created 25th Apr 2024 at 00:19 by Georgina Samaha

Merge pull request #20 from Sydney-Informatics-Hub/config

Configure for Gadi

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Samaha, G. (2024). Parabricks-Genomics-nf. WorkflowHub.

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Created: 25th Apr 2024 at 00:19

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