BY-COVID Baseline Use Case: SARS-CoV-2 Vaccine(s) effectiveness in preventing SARS-CoV-2 infection

Background information

Task 5.2 aims to demonstrate how mobilisation of real-world population, health and care data across national borders can provide answers to policy-relevant research questions. Eventually, it aims to prototype a workflow that is standard for population health research. Here, the research question is approached by identifying a causal effect that allows to evaluate a public health intervention. As such, a methodology for approaching causal inference when conducting federated research is proposed and demonstrated, guaranteeing different layers of interoperability (i.e., legal, organisational, and semantic interoperability).

The methodological framework comprises the following steps:

  • Defining the research question and the exposure-outcome relationship
  • Establishing a causal model using Directed Acyclic Graphs (DAGs)
  • Translating the causal model into data requirements using a Common Data Model (CDM)
  • Generating synthetic data and developing an interoperable analytical pipeline
  • Mobilising individual-level data within each of the nodes and transforming the data to comply with the CDM
  • Deploying the interoperable analytical pipeline within the secure processing environment (SPE) of each of the nodes (Data Hubs)
  • Meta-analysis of the aggregated results

Use case

The current use case aims to answer the following research question: "How effective have the SARS-CoV-2 vaccination programmes been in preventing SARS-CoV-2 infections?"

For more information, please consult the study protocol.

Space: BeYond-COVID (BY-COVID)


Funding codes:

Public web page:

Organisms: Sars-cov-2

WorkflowHub PALs: No PALs for this Team

Team start date: 13th Oct 2021

Team end date: 30th Oct 2024

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