Research Object Crate for EJP-RD WP13 case-study CAKUT momix analysis

Original URL: https://workflowhub.eu/workflows/126/ro_crate?version=1

Joint multi-omics dimensionality reduction approaches for CAKUT data using peptidome and proteome data **Brief description** In (Cantini et al. 2020), Cantini et al. evaluated 9 representative joint dimensionality reduction (jDR) methods for multi-omics integration and analysis and . The methods are Regularized Generalized Canonical Correlation Analysis (RGCCA), Multiple co-inertia analysis (MCIA), Multi-Omics Factor Analysis (MOFA), Multi-Study Factor Analysis (MSFA), iCluster, Integrative NMF (intNMF), Joint and Individual Variation Explained (JIVE), tensorial Independent Component Analysis (tICA), and matrix-tri-factorization (scikit-fusion) (Tenenhaus, Tenenhaus, and Groenen 2017; Bady et al. 2004; Argelaguet et al. 2018; De Vito et al. 2019; Shen, Olshen, and Ladanyi 2009; Chalise and Fridley 2017; Lock et al. 2013; Teschendorff et al. 2018; Žitnik and Zupan 2015). The authors provided their benchmarking procedure, multi-omics mix (momix), as Jupyter Notebook on GitHub (https://github.com/ComputationalSystemsBiology/momix-notebook) and project environment through Conda. In momix, the factorization methods are called from an R script, and parameters of the methods are also set in that script. We did not modify the parameters of the methods in the provided script. We set factor number to 2.

Author
Ozan Ozisik, Juma Bayjan, Cenna Doornbos, Friederike Ehrhart, Matthias Haimel, Laura Rodriguez-Navas, José Mª Fernández, Eleni Mina, Daniël Wijnbergen
License
GPL-3.0

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